Obeticholic Acid inter. OB-4

Obeticholic Acid inter. OB-4 - Names and Identifiers

Name	(E\|Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid Methyl ester
Synonyms	N-3 OB-4 Obeticholic Acid inter. OB-4 (3alpha,5beta)-6-Ethylidene-3-hydroxy-7-oxocholan-24-oic acid methyl ester
CAS	863239-59-2

Obeticholic Acid inter. OB-4 - Physico-chemical Properties

Molecular Formula	C27H42O4
Molar Mass	430.61998
Boling Point	534.3±43.0 °C

Obeticholic Acid inter. OB-4 - A method for the synthesis of an intermediate of aprocholic acid

from Baidu library

Application (Patent) No.:

CN201710202448.5

date of application:

2017-03-30

public/announcement number:

CN106916196A

date of publication/announcement:

2017.07.04

Applicant (patentee):

chengdu lvlin technology co., ltd

Inventor:

Liang zhengquan , yellow pine , Dong Qiang ,< a href = "https://xueshu.baidu.com/s?wd=author: (Zhou Cai'e) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Zhou Cai'e

national and provincial code:

CN510112

Summary:

The present invention discloses a synthesis method of the intermediate of Obeticholic acid, using sodium bromide, sulfuric acid and sodium bromate solution as raw materials, the oxidation of chenodeoxycholic acid to 3α hydroxyl 7 ketone group 5 beta choline acid (I). In order to solve the problems of cumbersome post-treatment, long treatment time and low yield in the synthesis of the existing 3α hydroxyl 7 ketone 5 β cholanic acid (I) industry, the synthesis method provided by the present invention reduces the controllable cost in the production process, reduces the cumbersome operation and safety problems, is conducive to industrial production, and is conducive to further improving the yield and quality of oberacholic acid, reducing production costs, and improving, reduce impurity content.

Last Update：2024-01-02 23:10:35

Obeticholic Acid inter. OB-4 - Obeticholic acid intermediate and its preparation method and application

from Baidu library

patent type:

patent for invention

application (patent) number:

CN201611203526.5

date of application:

20161223

public/announcement number:

CN108239134A

date of publication/announcement:

20180703

Applicant (patentee):

Shanghai bobang pharmaceutical technology co., ltd

Inventor:

Gao Heyong ,< a href = "https://xueshu.baidu.com/s?wd=author: (Liu Shengquan) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Liu Shengquan ,< a href = "https://xueshu.baidu.com/s?wd=author: (Bi Pengfei) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Bi Pengfei , Sun Bingyang , Liu Zhende

national and provincial code:

CN310115

Summary:

The present invention discloses an auticholic acid intermediate and a preparation method and application thereof. The intermediate has the chemical structure shown in Formula III and Formula IV respectively: the use of the intermediate of the present invention to synthesize auticholic acid has the advantages of high total molar yield, simple operation, high three-dimensional selectivity, safety and no pollution, no special requirements for equipment, low production cost, etc., and has strong practical value for realizing the industrialization of auti, significant progress compared to the existing technology.

Last Update：2023-08-16 22:23:51

Obeticholic Acid inter. OB-4 - A method for preparing an intermediate of aprocholic acid by a fixed-bed reactor

from Baidu library

patent type:

patent for invention

application (patent) number:

CN202011624507.6

date of application:

20201230

public/announcement number:

CN112724187A

date of publication/announcement:

20210430

Applicant (patentee):

Nanjing youjie pharmaceutical technology co., ltd

Inventor:

fu mingwei , Wang Huaiqiu , Xiao Ya

national and provincial code:

CN320106

Summary:

The present invention discloses a method for continuous hydrogenation of a fixed bed to prepare an Obeticholic acid intermediate. The Obeticholic acid intermediate 1 is reacted with hydrogen in a fixed bed reactor filled with a catalyst; the structural formula of the Obeticholic acid intermediate 1 is shown in (I); the catalyst is palladium/carbon, palladium/aluminum oxide, platinum/carbon, one or more mixtures of platinum/aluminum trioxide or nickel/silica; the present invention not only has fast reaction speed, high conversion rate, simple and safe operation process, but also has low cost, can be carried out continuously, and can reduce the problem of three wastes.

Last Update：2023-08-16 22:23:51

Shanghai Amole Biotechnology Co., Ltd.

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